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RETIN-A (TRETINOIN) CREAM, GEL, LIQUID: PATIENT INFORMATION

This leaflet tells you about Retin-A (Tretinoin) acne treatment as prescribed by your physician. this product is to be used only according to your doctor's instructions, and it should not be applied to other areas of the body or to other growths or lesions. the long-term safety and effectiveness of this product in other disorders have not been evaluated. if you have any questions, be sure to ask your doctor or pharmacist.


Precautions

The effects of the sun on your skin

As you know, overexposure to natural sunlight or the artificial sunlight of a sunlamp can cause sunburn. Overexposure to the sun over many years may cause premature aging of the skin and even skin cancer. The chance of these effects occurring will vary depending on skin type, the climate and the care taken to avoid overexposure to the sun. Therapy with Retin-A cream, gel and liquid may make your skin more susceptible to sunburn and other adverse effects of the sun, so unprotected exposure to natural or artificial sunlight should be minimized.

Laboratory findings

When laboratory mice are exposed to artificial sunlight, they often develop skin tumors. These sunlight-induced tumors may appear more quickly and in greater number if the mouse is also topically treated with the active ingredient in Retin-A, tretinoin. In some studies, under different conditions, however, when mice treated with tretinoin were exposed to artificial sunlight, the incidence and rate of development of skin tumors was reduced. There is no evidence to date that tretinoin alone will cause the development of skin tumors in either laboratory animals or humans. However, investigations in this area are continuing.

Use caution in the sun

When outside, even on hazy days, areas treated with Retin-A should be protected. An effective sunscreen should be used any time you are outside (consult your physician for a recommendation of an SPF level which will provide you with the necessary high level of protection). For extended sun exposure, protective clothing, like a hat, should be worn. Do not use artificial sunlamps while you are using Tretinoin (Retin-A). If you do become sunburned, stop your therapy with this medication until your skin has recovered.

Avoid excessive exposure to wind or cold

Extremes of climate tend to dry or burn normal skin. Skin treated with Retin-A may be more vulnerable to these extremes. Your physician can recommend ways to manage your acne treatment under such conditions.

Possible problems

The skin of certain sensitive individuals may become excessively red, swollen, blistered or crusted. If you are experiencing severe or persistent irritation, discontinues the use of Tretinoin (Retin-A) gel, cream, and liquid and consult your physician.

There have been reports that, in some patients, areas treated with Retin-A developed a temporary increase or decrease in the amount of skin pigment (color) present. The pigment in these areas returned to normal either when the skin was allowed to adjust to Retin-A (Tretinoin) or therapy was discontinued.

Use other medication only on your physician's advice

Only your physician knows which other medications may be helpful during treatment and will recommend them to you if necessary. Follow the physician's instructions carefully. In addition, you should avoid preparations that may dry or irritate your skin. These preparations may include certain astringents, toiletries containing alcohol, spices or lime, or certain medicated soaps, shampoos and hair permanent solutions. Do not allow anyone else to use this medication.

Do not use other medications with Retin-A (Tretinoin) cream, gel and liquid which are not recommended by your doctor. The medications you have used in the past might cause unnecessary redness or peeling.

If you are pregnant, think you are pregnant or are nursing an infant

No studies have been conducted in humans to establish the safety of Retin-A in pregnant women. If you are pregnant, think you are pregnant, or are nursing a baby, consult your physician before using the medication.


While you're on Retin-A therapy

Use a mild, non-medicated soap. Avoid frequent washings and harsh scrubbing.

Acne isn't caused by dirt, so no matter how hard you scrub, you can't wash it away. Washing too frequently or scrubbing too roughly may at times actually make your acne worse. Wash your skin gently with a mild bland soap. (Two or three times a day should be sufficient). Pat skin dry with a towel. Let the face dry 20-30 minutes before applying Retin-A (Tretinoin). Remember, excessive irritation such as rubbing, too much washing, use of other medications not suggested by your physician, etc., may worsen your acne.


How to use Retin-A (Tretinoin)?

To get the best results with Retin-A therapy, it is necessary to use it properly. Forget about the instructions given for other products and the advice of friends. Just stick to the special plan your doctor has laid out for you and be patient. Remember, when Retin-A (Tretinoin) gel, cream, and liquid is used properly, many users see improvement by 12 weeks. Again, follow instructions - be patient - don't start and stop therapy on your own - if you have questions, ask you doctor.

To help you use the medication correctly, keep these simple instructions in mind.

  • Apply Retin-A cream, gel and liquid once daily before bedtime, or as directed by your physician. Your physician may advise, especially if your skin is sensitive, that you start your therapy by applying Retin-A every other night. First, wash with a mild soap and dry your skin gently. Wait 20 to 30 minutes before applying the medication; it is important for skin to be completely dry in order to minimize possible irritation.
  • It is better not to use more than the amount suggested by your physician or to apply more frequently than instructed. Too much may irritate the skin, waste medication and won't give faster or better results.
  • Keep the medication away from the corners of the nose, mouth, eyes and open wounds. Spread away from these areas when applying.
  • Retin-A Cream: Squeeze about a half inch or less of medication onto the fingertip. While that should be enough for your whole face, after you have some experience with the medication you may find you need slightly more or less to do the job. The medication should become invisible almost immediately. If it is still visible, you are using too much. Cover the affected area lightly with Retin-A (Tretinoin) cream by first dabbing it on your forehead, chin and both cheeks, then spreading it over the entire affected area. Smooth gently into the skin.
  • Retin-A Gel: Squeeze about a half inch or less of medication onto the fingertip. While that should be enough for your whole face, after you have some experience with the medication you may find you need slightly more or less to do the job. The medication should become invisible almost immediately. If it is still visible, or if dry flaking occurs from the gel within a minute or so, you are using too much. Cover the affected area lightly with Retin-A (Tretinoin) Gel by first dabbing it on your forehead, chin and both cheeks, then spreading it over the entire affected are. Smooth gently into the skin.
  • Retin-A Liquid. This medicine may be applied to the skin where acne lesions appear, spreading the medication over the entire affected area, using a fingertip, gauze pad, or cotton swab. If gauze or cotton is employed, care should be taken not to oversaturate it to the extent that the liquid would run into area where treatment is not intended (such as corners of the mouth, eyes, and nose).
  • It is recommended that you apply a moisturizer or a moisturizer with sunscreen that will not aggravate your acne (noncomedogenic) every morning after you wash.


    What to expect with your new treatment?

    Retin-A (Tretinoin) works deep inside your skin and this takes time. You cannot make this drug work any faster by applying more than one dose each day, but an excess amount of Retin-A may irritate your skin. Be patient.

    There may be some discomfort or peeling during the early days of treatment. Some patients also notice that their skin begins to take on a blush.

    These reactions do not happen to everyone. If they do, it is just your skin adjusting to Retin-A cream, gel and liquid and this usually subsides within two to four weeks. These reactions can usually be minimized by following instructions carefully. Should the effects become excessively troublesome, consult your doctor, pharmacist, or other healthcare professional.

    By three to six weeks, some patients notice an appearance of new blemishes (papules and pustules). At this stage it is important to continue using Retin-A.

    If Tretinoin (Retin-A) is going to have a beneficial effect for you, you should notice a continued improvement in your appearance after 6 to 12 weeks of therapy. Don't be discouraged if you see no immediate improvement. Don't stop treatment at the first signs of improvement.

    Once your acne is under control you should continue regular application of Retin-A until your physician instructs otherwise.


    If you have questions

    All questions of a medical nature should be taken up with your physician. For more information about Retin-A (Tretinoin) cream, gel and liquid, call Ortho Dermatological.

    Manufactured and distributed by Janssen, Ortho-McNeil Pharmaceutical companies and their divisions.

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